There has been very little between England and Scotland of late so you may be tempted by bet365's offer of 11/2 for an England win between 6-10 points. Or do you fancy Scotland debutant Scott Maitland to grab a try on his debut? Bet365 have the New Zealand-born winger at 14/1 to grab the first try or 7/2 to cross the whitewash at any point in the game.
Ireland centre Brian O'Driscoll is clearly a fan of the Millennium Stadium having scored six tries in 12 visits to the Welsh capital but bet365 are still offering 14/1 for him to score the game's opening try and 7/2 to score at anytime. Or maybe you fancy Wales to snap their losing streak? Bet365 are offering 40/1 on Wales winger Alex Cuthbert grabbing the first try and the hosts winning between 6-10 points.
Think Italy can repeat their 2011 triumph? It's 7/1 for a home victory at the Stadio Olimpico. Or maybe you think Italy will open the scoring with a drop goal to give a bumper home crowd something to cheer and France something to worry about? That can be backed at 16/1.